Upload protein sequences
Combine multiple FASTA files, accession sequences, PDB/mmCIF protein chains, and pasted FASTA records. Your scanned protein and optional BLAST homologs are retained. ESplore calculates ESM-2 embeddings and performs embedding-space analysis.
Upload FASTA or protein structures
Select one or more files to append sequences.
Fetch sequences
Accession sequences are appended; PDB entries include chain choices and structural coordinates.
Structure chain selection
Select an additional chain to append it with coordinates.
Paste protein FASTA records or a raw protein sequence
Selected user sequences
0 user sequencesNo sequences have been added yet.
Additional sequences are retained when you append more inputs.
Exact distinct counts are determined after submission.
Provide FASTA sequences to enable Continue.
Standalone submissions accept up to 10,000 distinct custom, query and BLAST proteins after deduplication (each 1–1,022 residues; up to 160 MB per FASTA file). Pfam analyses can combine up to 100,000 public proteins with 10,000 custom proteins, for 110,000 total. More than 1,000 proteins use the Phase II embedding-space analysis. Permanent ESM-2 embeddings are checked first; only jobs requiring more than 100 new embeddings consume one of 50 large-job slots per rolling 24 hours. Uploaded proteins remain private.
Embedding analysis
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